ParkinsonCanadaV1, Main, Exploration, bibRecord, 000E76

SLC1A2 rs3764087 does not associate with essential tremor

Identifieur interne : 000E76 ( Main/Exploration ); précédent : 000E75; suivant : 000E77

SLC1A2 rs3764087 does not associate with essential tremor

Auteurs : Jay P. Ross [Canada] ; Sruti Rayaprolu [États-Unis] ; Cecily Q. Bernales [Canada] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Jay Van Gerpen [États-Unis] ; Ryan J. Uitti [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Alex Rajput [Canada] ; Ali H. Rajput [Canada] ; Michele L. Rajput [Canada] ; Owen A. Ross [États-Unis] ; Carles Vilari O-Güell [Canada]

Source :

Neurobiology of aging [ 0197-4580 ] ; 2013.

RBID : PMC:4388040

Abstract

A recent genome-wide association study of essential tremor (ET) patients from Germany has nominated SLC1A2 rs3764087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET we genotyped rs3764087 in a North American series consisting of 1,356 ET patients and controls. Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and ET patients (p>0.36). These findings therefore do not support a role for SLC1A2 rs3764087 in the susceptibility to ET in the North American population. Further studies in ethnically distinct populations of ET patients are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388040

DOI: 10.1016/j.neurobiolaging.2013.09.022
PubMed: 24139280
PubMed Central: 4388040

Affiliations:

Canada, États-Unis

Le document en format XML

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 rs3764087 does not associate with essential tremor</title>
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 rs3764087 does not associate with essential tremor</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">A recent genome-wide association study of essential tremor (ET) patients from Germany has nominated <italic>SLC1A2</italic>
 rs3764087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of <italic>SLC1A2</italic>
 in ET we genotyped rs3764087 in a North American series consisting of 1,356 ET patients and controls. Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and ET patients (p>0.36). These findings therefore do not support a role for <italic>SLC1A2</italic>
 rs3764087 in the susceptibility to ET in the North American population. Further studies in ethnically distinct populations of ET patients are necessary to understand whether genetic variability in <italic>SLC1A2</italic>
 affects disease risk for ET.</p>
</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

SLC1A2 rs3764087 does not associate with essential tremor

SLC1A2 rs3764087 does not associate with essential tremor

Source :

Abstract

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Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.